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Last Updated: 12/23/2024

Oxycodone with aspirin

Drug Name(s): generic

Class: Analgesics

Uses

Moderate to moderately severe pain.

Dosage

Form(s): tablet 

Begin with one tablet every 6 hours as needed for pain. Dose may be adjusted until you achieve adequate pain relief. Do not take more than 4 grams of aspirin daily. 

 

Special Instructions

Do not increase the dose on your own or stop treatment abruptly unless told to do so by a doctor. Do not drive, operate machinery or perform other potentially dangerous activities until you know whether the medication will affect your ability to do them safely.

Do not take with aspirin or other products containing aspirin unless told to do so by a doctor.

Potential Side Effects

Abdominal pain, constipation, diarrhea, drowsiness, headache, itching, lightheadedness, nausea, nervousness, physical and mental impairment, upset stomach, vomiting, rash, sweating

Be Aware

Confusion, deafness, dizziness or ringing in the ears is a sign that you are taking too much of this drug. If you are taking more than 3,600 mg of aspirin per day, your doctor should monitor salicylate levels in your blood. 

Opioids can slow breathing and suppress the cough reflex. Before taking an opioid, tell your doctor if you have a history of lung disease or breathing difficulties. Taking opioids with certain other drugs can increase the risk of dangerous side effects. Especially tell your doctor if you take antihistamines (allergy medications), tranquilizers, sleeping pills, muscle relaxants or other pain medication, or if you have a history of alcohol or drug abuse.

Call 911 if you experience signs of an overdose: confusion, extreme sleepiness and fainting, shallow breathing, extreme muscle weakness or twitching muscles, heavy sweating, constricted pupils, slurred speech, chest pain or rapid heartbeat. Call your doctor if you have thoughts of suicide, abnormal fear or anxiety; swelling in ankles or feet, or blood in your stool.

Ulcers and internal bleeding can occur without warning. Before taking any type of NSAID, also tell your doctor if you drink alcohol or take blood thinners (including warfarin), ACE inhibitors, lithium or furosemide. Avoid aspirin and other salicylates. Also report any sensitivity or allergy to aspirin or similar drugs. Do not take NSAIDs late in pregnancy.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.