Rheumatoid Arthritis

Advancing Science for Better RA Treatments

Rheumatoid Arthritis

The Arthritis Foundation is committed to advancing science to discover better treatments for autoimmune and inflammatory forms of arthritis like rheumatoid arthritis (RA), psoriatic arthritis, juvenile idiopathic arthritis and others. This commitment is part of our legacy. The Arthritis Foundation was behind one of the earliest clinical trials that set the stage for methotrexate to become a mainstay of treatment for RA. The discovery of the protein interleukin-1 receptor alpha (IL-1Rα), the target of the FDA-approved drug anakinra (Kineret), arose in part from research we funded and helped usher in the era of biologics.

In 2021, we renewed our commitment to advancing the science of RA by launching the RA Research Program. Working with a group of experts from government and academia, we have refined our priorities in RA research to focus on the underlying causes of treatment-resistant RA. By supporting such research, we aim to improve the lives of people with RA for whom currently available therapies are ineffective.

Working Group

The Arthritis Foundation’s Medical and Scientific Advisory Committee in 2021 assembled an RA Working Group of RA experts to help refine and focus our priorities in rheumatoid arthritis research.

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RFP on Refractory RA Research

Characterizing Determinants of Response and Nonresponse to Current RA Therapeutic Agents (closed)

This RFP invites applications for characterization of the distinct mechanisms, biomarkers, and therapeutic targets that distinguish RA responders and non-responders to therapy.

2022 RA Research Program Awardees

Learn more in our press release

Rebecca Blank, MD, PhD

Institution: New York University Grossman School of Medicine
Grant title: Modifying the gut microbiome and systemic immune response to enhance methotrexate efficacy in rheumatoid arthritis patients with inadequate response
Award mechanism: Pilot award
Amount awarded: $74,995
Award duration: 1 year

Susan Goodman, MD

Institution: Hospital for Special Surgery
Grant title: Characterizing Targets in Refractory RA
Award mechanism: Large award
Amount awarded: $450,000
Award duration: 3 years

Elaine Husni, MD, MPH

Institution: Cleveland Clinic
Grant title: Defining a Personalized
Treatment Approach to Rheumatoid Arthritis: Using Genetic Markers of TNFi Response
Award mechanism: Pilot award
Amount awarded: $75,000
Award duration: 1 year

Dan Solomon, MD, MPH

Institution: Brigham and Women's Hospital, Inc.
Grant title: Defining immune cell phenotypes and cell functions that distinguish treatment responders and non-responders in RA: towards development of a liquid biopsy to personalize treatment
Award mechanism: Large award
Amount awarded: $450,000
Award duration: 3 years

RA Publications

Recent Publications

2021 ACR Guideline for the Treatment of Rheumatoid Arthritis

The American College of Rheumatology (ACR) published its 2021 guideline for treating rheumatoid arthritis.

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Stay in the Know. Live in the Yes.

Get involved with the arthritis community. Tell us a little about yourself and, based on your interests, you’ll receive emails packed with the latest information and resources to live your best life and connect with others.

I Want to Contribute
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  • Donate


    Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life.

  • Volunteer


    Join us and become a Champion of Yes. There are many volunteer opportunities available.

  • Live Yes! INSIGHTS

    Live Yes! INSIGHTS

    Take part to be among those changing lives today and changing the future of arthritis.

  • Partner


    Proud Partners of the Arthritis Foundation make an annual commitment to directly support the Foundation’s mission.


Ways to Give

Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Whether it is supporting cutting-edge research, 24/7 access to one-on-one support, resources and tools for daily living, and more, your gift will be life-changing.

Make a Donation

Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. Please, make your urgently-needed donation to the Arthritis Foundation now!

Become a Member

Become an Arthritis Foundation member today for just $20 and you'll receive access to helpful tools..... and more. 

Make a Honor or Memorial Gift

Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift.

Gift Planning

I want information on ways to remember the AF in my will, trust or other financial planning vehicles.


Volunteer Opportunities

The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

Become a Volunteer

More About Volunteering


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community. 

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families. 

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

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Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.


Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000


Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.


Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.


Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.


Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.


Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.