Publications

The Arthritis Foundation Science Staff, our funded scientists, and our partners contribute to the medical and scientific discourse by producing peer-reviewed manuscripts, guidelines, articles, white papers, and presentations. Read, review, and learn about the important work of science and research accomplished in rheumatoid arthritis (RA), osteoarthritis (OA), juvenile arthritis (JA) and the many related arthritidies.  

Raman needle arthroscopy for in vivo molecular assessment of cartilage

This manuscript describes research regarding a new type of diagnostic technology, “optical biopsy”, for cartilage of OA patients.  This project was led by Arthritis Foundation funded scientist Michael Albro.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/34370873/

Forward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1

This manuscript describes research to elucidate how cartilage is broken down in an arthritic joint, could spur development of treatments that prevent the breakdown.  This project was led by Arthritis Foundation funded scientist Suneel Apte.  Aspects of this project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35339693/

MOCHA Trial: study protocol for a double-blind, randomized, placebo-controlled clinical trial

Technical description of the AF-funded OACTN study called MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.  This project was led by Arthritis Foundation funded scientist Cale Jacobs.  This project was funded by the Arthritis Foundation. 

https://pubmed.ncbi.nlm.nih.gov/35101085/

The QIBA Profile for MRI-based Compositional Imaging of Knee Cartilage

Technical description of a new MRI technique for imaging knee cartilage to show biomechanical and microstructural changes for early OA.  This project was led by Arthritis Foundation funded scientist Xiaojuan Li.  Aspects of this project was funded by and contains contributions from the Arthritis Foundation and AF Science Staff. 

https://pubmed.ncbi.nlm.nih.gov/34491127/

OA Drug Development Workshop Technical Highlights

A technical overview of the workshop, including clinical research challenges, biomarkers, and assessment of disease progression by AF Science Staff

https://www.arthritis.org/science/events-publications/oa-workshop-technical-highlights

OA Drug Development Workshop Presentations and Papers

Experts discussed many aspects of OA and development of drugs.  Topics included the epidemiology, challenges to assessing disease progression, potential biomarkers, difficulties evaluating long-term benefits to the patient, and other challenges to achieving FDA approval.  The workshop was co-sponsored by the FDA and the AF.

https://www.arthritis.org/science/events-publications/oa-drug-development-workshop-presentations-papers

2021 ACR Guideline for the Treatment of Rheumatoid Arthritis

The American College of Rheumatology (ACR) published its 2021 guideline for rheumatoid arthritis treatments.

https://pubmed.ncbi.nlm.nih.gov/34101387/

2019 ACR/AF Guideline for Management of OA of the Hand, Hip, and Knee

The ACR and AF organized expert committees to publish the 2019 guideline for OA management in hand, hip, and knee.

https://pubmed.ncbi.nlm.nih.gov/31908149/

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