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Last Updated: 12/23/2024

Oxycodone with ibuprofen

Drug Name(s): generic

Class: Analgesics

Type: Opioid

Used in the short-term management of acute, moderate to severe pain.

Dosage

Form(s): tablet 

In combination pill, 5 mg oxycodone and 400 mg ibuprofen every 6 hours as needed.

Dosage should not exceed 4 tablets in a 24-hour period and should not exceed 7 days.

Special Instructions

Do not take with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).

Do not increase the dose on your own or stop treatment abruptly unless told to do so by a doctor.

Do not drive, operate machinery or perform other potentially dangerous activities until you know whether the medication will affect your ability to do them safely.

Potential Side Effects

Constipation; dizziness; drowsiness; dry mouth; headache; increased sweating; itching of skin; nausea; shortness of breath; vomiting; weakness

Be Aware

This medicine contains ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). Before taking any type of NSAID, tell your doctor if you drink alcohol or take blood thinners (including warfarin), ACE inhibitors, lithium or furosemide. Also report any sensitivity or allergy to aspirin or similar drugs. All NSAIDs may cause an increased risk of serious blood clots, heart attacks and stroke, which can be fatal. This risk may increase with dose and duration of use. Patients who have or who are at risk for cardiovascular disease may be at greater risk for these complications. NSAIDs should not be used for pain if you are going to have coronary bypass surgery. Do not take NSAIDs late in pregnancy.

Opioids can slow breathing and suppress the cough reflex. Before taking an opioid, tell your doctor if you have a history of lung disease or breathing difficulties. Taking opioids with certain other drugs — including alcohol, benzodiazepines or anti-cancer agents known as CYP3A4 inhibitors — can increase the risk of dangerous side effects and death. Especially tell your doctor if you take antihistamines (allergy medications), tranquilizers, sleeping pills, muscle relaxants or other pain medication, or if you have a history of alcohol or drug abuse.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.