Advancing Osteoarthritis Treatments

Osteoarthritis (OA) is the most prevalent form of joint disease, affecting 30.8 million adults in the United States.

OA entails all aspects of a serious condition, ranging in levels of disability severity from mild to severe with constant chronic pain, progressive, irreversible structural damage and gradual loss of function. Pain from arthritis is one of the key barriers to maintaining physical activity and can be considered a critical factor in the onset of frailty in the elderly. The more severe the walking disability, the higher the risk of death. The impact of OA is complex, multi-factorial and persistently progressive.

There is no cure for osteoarthritis and the plethora of treatment options which aim to reduce symptoms and improve the quality of life are lacking in one or both aspects. There is an urgent need for trials of new and existing drugs which may intervene in the development and progression of OA. Importantly, therapies must improve how a patient feels, functions and survives.

OA virtual Center of Excellence (COE)

The Arthritis Foundation is transforming the landscape of OA research and discovery by focusing on what is paramount for our patients - biomarkers to diagnose the disease early and allow intervention as soon as possible as opposed to solely studying treatments of end stage disease when reduced or no options exist.

Our COE will allow researchers and patients from multiple organizations around the country to interact and share information that will help us:

  • Break down time and resource barriers
  • Accelerate FDA approval of new therapies
  • Connect a community of partners to best manage Osteoarthritis disease, ensuring patients live their YES! 

Clinical Trial Network

Breaking down time and resource barriers
We have established a multi-center clinical trial network with our virtual OA COE. It provides a full spectrum of research support, including clinical expertise, trial design guidance, patient cohorts, imaging modalities, biomarker testing as well as patient-reported outcomes and data analysis. Investigators collaborating with the OA COE Clinical Trial Network will share:

  • Design standards, protocols, laboratories, reading centers and training.
  • Access to clinical trial design, drug development and licensing expertise.
  • Pathways for further development of de-risked molecules.
  • Outreach programs within the local community create private practice extension centers to accelerate patient
  • recruitment for trials.
  • Process enhancements and innovative design features are leveraged such as adaptive trials and shared placebo groups.
  • New and updated technology to expedite data analysis, improve quality, and standardize reporting of outcomes.
  • The Clinical Trial Network is reducing logistical and financial barriers for conducting trials.

Clinical trials conducted within the OA COE Clinical Trial Network will select outcomes which are most meaningful to our patients as patients are engaged in all aspects of design, recruitment, conduct and governance. Importantly, patients will have the opportunity to be matched with trials of interest.


By giving us 10 minutes, you become part of a force that will change the lives of the more than 54 million people with arthritis. Your voice matters.

I Want to Contribute
I Need Help
  • Donate


    Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life.

  • Volunteer


    Join us and become a Champion of Yes. There are many volunteer opportunities available.

  • Live Yes! INSIGHTS

    Live Yes! INSIGHTS

    Take part to be among those changing lives today and changing the future of arthritis.

  • Partner


    Proud Partners of the Arthritis Foundation make an annual commitment to directly support the Foundation’s mission.


Ways to Give

Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Whether it is supporting cutting-edge research, 24/7 access to one-on-one support, resources and tools for daily living, and more, your gift will be life-changing.

Make a Donation

Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. Please, make your urgently-needed donation to the Arthritis Foundation now!

Become a Member

Become an Arthritis Foundation member today for just $20 and you'll receive access to helpful tools..... and more. 

Make a Honor or Memorial Gift

Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift.

Gift Planning

I want information on ways to remember the AF in my will, trust or other financial planning vehicles.


Volunteer Opportunities

The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

More About Volunteering


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community. 

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families. 

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

Get Started


Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.


Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000


Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.


Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.


Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.


Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.


Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.