Probenecid
Drug Name(s): generic only
Class: Uric acid drugs
Type: Uricosuric
Used to reduce serum uric acid concentrations in patients with frequent disabling gout attacks or gout accompanied by tophi, masses of uric acid crystals that develop around the joint and tissues.
Dosage
Form(s): tablet
500 to 3,000 mg daily in two or three doses.
Special Instructions
Do not drink alcohol when taking this medication.
Do not take with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
Drink plenty of fluids while taking this medication.
Take with food or an antacid.
Potential Side Effects
Anemia; dizziness; fever; flushing; headache; loss of appetite; itching; increased urination; nausea; rash; sore gums; vomiting
Be Aware
Probenecid may initially increase the frequency of gout attacks during the first 6 to 12 months of use, but it will ultimately help prevent them. Your doctor may prescribe another medication, such as colchicine, to decrease this effect. Inform your doctor about all prescription and nonprescription medications you are currently taking. Additionally, let your doctor know if you have a history of ulcers, kidney stones, kidney disorders, or blood disorders.
If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor. If you become pregnant while taking probenecid, contact your doctor immediately.
Also, inform your doctor if you are planning to undergo surgery that involves a general anesthetic.
If you are having any urine tests, notify your doctor and the laboratory personnel that you are taking probenecid, as it may affect test results.
