Drug Class: Uric acid drugs (Anti-inflammatory)
Brand Names: Colcrys, Golperba, Mitigare


For prevention: 0.6 to 1.2 mg daily in one or two doses. (Maximum dose is 1.2 mg/day.)

To stop acute attacks (Colcrys only): 1.2 mg at the first sign of a flare followed by 0.6 mg an hour later.

Potential Side Effects

Diarrhea; nausea; nerve pain; vomiting; stomach pain.

Special Instructions 

You should not take grapefruit and grapefruit juice while taking this drug, because doing so affects the levels of the drug in your body.

Drink plenty of fluids while taking this medication.

Stop taking this medication and call your doctor if you have diarrhea, nausea, stomach pain or vomiting.

Take with food or an antacid.

Be Aware

Before taking colchicine, tell your doctor if you take NSAIDs, cancer medications, heparin, nitrofurantoin or zidovudine. Special caution is required in people who have an ongoing infection or who are using immunosuppressive drugs. Death due to colchicine toxicity have been reported in patients taking this medication with certain antibiotics and antifungals, particularly clarithromycin (Biaxin). Make sure your doctor knows about your entire health history.

                                                                                   LAST UPDATED: 03/07/2019

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.