Featured Clinical Trials 

Arthritis Foundation-funded studies aim to find new treatment options using clinical science focused on humans. The sooner patients are recruited, the sooner we’ll see results. See more below. 

Image Testing to Prevent Post-Traumatic OA 

This trial tests the value of a new low-cost, low-dose standing CT system in detecting arthritic changes in ankle fractures as well as changes in ankle pain and function. For ages 18-70 who sustained an intra-articular fracture of the tibial plafond and had treatment within four weeks of injury. Location: University of Iowa Hospitals and Clinics 

Corticosteroid Meniscectomy Randomized Trial 

This trial seeks a better understanding of synovitis and the kind of treatment needed to improve patient outcomes after undergoing knee arthroscopic partial meniscectomy. For ages 40+ with arthroscopic evidence of structural OA including at least one surface with grade 2 chondral change. Location: Cleveland Clinic 

Potential Treatment After ACL Reconstruction 

This trial explores the novel use of oral montelukast as a potential disease-modifying treatment to prevent irreversible cartilage lost after anterior cruciate ligament injury. For ages 25-50 who have undergone primary ACL reconstruction with concomitant meniscus injury. Locations: University of Kentucky, Duke University, Cleveland Clinic, UCSF 

Optimizing Gait Biomechanics for PTOA Prevention 

This trial will report the initial effects of real-time gait biofeedback to gauge indicators of early post-traumatic OA development in those with anterior cruciate ligament reconstruction. For ages 18-35 who underwent ACLR 6-24 months prior to enrollment. Location: University of North Carolina, Chapel Hill 

Multi-Site Novel Accelerated MRI Relaxometry 

This trial aims to develop novel, fast and reproducible imaging methods on MR systems to fill an unmet clinical need for robust assessment of early changes in cartilage health. For ages 18-50 who sustained an acute full ACL tear in one knee with the contralateral knee uninjured. Locations: Cleveland Clinic Foundation, UCSF, University of Kentucky, Albert Einstein College of Medicine 

ACL Reconstruction Outcomes 10 Years Later 

In this trial, investigators will examine patients undergoing unilateral ACL reconstruction surgery to determine risk factors for osteoarthritis 10 years post-surgery. For ages 20-50 who had their surgery performed by specific doctors at specific facilities listed and participated in the two-year onsite visit. Locations: Vanderbilt University, Ohio State University, Cleveland Clinic 

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  • Donate


    Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life.

  • Volunteer


    Join us and become a Champion of Yes. There are many volunteer opportunities available.

  • Live Yes! INSIGHTS

    Live Yes! INSIGHTS

    Take part to be among those changing lives today and changing the future of arthritis.

  • Partner


    Proud Partners of the Arthritis Foundation make an annual commitment to directly support the Foundation’s mission.


Ways to Give

Every gift to the Arthritis Foundation will help people with arthritis across the U.S. live their best life. Whether it is supporting cutting-edge research, 24/7 access to one-on-one support, resources and tools for daily living, and more, your gift will be life-changing.

Make a Donation

Help millions of people live with less pain and fund groundbreaking research to discover a cure for this devastating disease. Please, make your urgently-needed donation to the Arthritis Foundation now!

Become a Member

Become an Arthritis Foundation member today for just $20 and you'll receive access to helpful tools..... and more. 

Make a Honor or Memorial Gift

Honor a loved one with a meaningful donation to the Arthritis Foundation. We'll send a handwritten card to the honoree or their family notifying them of your thoughtful gift.

Gift Planning

I want information on ways to remember the AF in my will, trust or other financial planning vehicles.


Volunteer Opportunities

The Arthritis Foundation is focused on finding a cure and championing the fight against arthritis with life-changing information, advocacy, science and community. We can only achieve these goals with your help. Strong, outspoken and engaged volunteers will help us conquer arthritis. By getting involved, you become a leader in our organization and help make a difference in the lives of millions. Join us and become a Champion of Yes.

Become a Volunteer

More About Volunteering


Give Just 10 Minutes.

Tell us what matters most to you. Change the future of arthritis.

By taking part in the Live Yes! INSIGHTS assessment, you’ll be among those changing lives today and changing the future of arthritis, for yourself and for 54 million others. And all it takes is just 10 minutes.

Your shared experiences will help:

- Lead to more effective treatments and outcomes
- Develop programs to meet the needs of you and your community
- Shape a powerful agenda that fights for you

Now is the time to make your voice count, for yourself and the entire arthritis community. 

Currently this program is for the adult arthritis community.  Since the needs of the juvenile arthritis (JA) community are unique, we are currently working with experts to develop a customized experience for JA families. 

How are you changing the future?

By sharing your experience, you’re showing decision-makers the realities of living with arthritis, paving the way for change. You’re helping break down barriers to care, inform research and create resources that make a difference in people’s lives, including your own.

Get Started


Meet Our Partners

As a partner, you will help the Arthritis Foundation provide life-changing resources, science, advocacy and community connections for people with arthritis, the nations leading cause of disability. Join us today and help lead the way as a Champion of Yes.


Our Trailblazers are committed partners ready to lead the way, take action and fight for everyday victories. They contribute $2,000,000 to $2,749,000


Our Visionary partners help us plan for a future that includes a cure for arthritis. These inspired and inventive champions have contributed $1,500,00 to $1,999,999.


Our Pioneers are always ready to explore and find new weapons in the fight against arthritis. They contribute $1,000,000 to $1,499,999.


Our Pacesetters ensure that we can chart the course for a cure for those who live with arthritis. They contribute $500,000 to $999,000.


Our Signature partners make their mark by helping us identify new and meaningful resources for people with arthritis. They contribute $250,000 to $499,999.


Our Supporting partners are active champions who provide encouragement and assistance to the arthritis community. They contribute $100,000 to $249,999.