Featured Clinical Trials
Arthritis Foundation-funded studies aim to find new treatment options using clinical science focused on humans. The sooner patients are recruited, the sooner we’ll see results. See more below.
Image Testing to Prevent Post-Traumatic OA
This trial tests the value of a new low-cost, low-dose standing CT system in detecting arthritic changes in ankle fractures as well as changes in ankle pain and function. For ages 18-70 who sustained an intra-articular fracture of the tibial plafond and had treatment within four weeks of injury. Location: University of Iowa Hospitals and Clinics
Corticosteroid Meniscectomy Randomized Trial
This trial seeks a better understanding of synovitis and the kind of treatment needed to improve patient outcomes after undergoing knee arthroscopic partial meniscectomy. For ages 40+ with arthroscopic evidence of structural OA including at least one surface with grade 2 chondral change. Location: Cleveland Clinic
Potential Treatment After ACL Reconstruction
This trial explores the novel use of oral montelukast as a potential disease-modifying treatment to prevent irreversible cartilage lost after anterior cruciate ligament injury. For ages 25-50 who have undergone primary ACL reconstruction with concomitant meniscus injury. Locations: University of Kentucky, Duke University, Cleveland Clinic, UCSF
Optimizing Gait Biomechanics for PTOA Prevention
This trial will report the initial effects of real-time gait biofeedback to gauge indicators of early post-traumatic OA development in those with anterior cruciate ligament reconstruction. For ages 18-35 who underwent ACLR 6-24 months prior to enrollment. Location: University of North Carolina, Chapel Hill
Multi-Site Novel Accelerated MRI Relaxometry
This trial aims to develop novel, fast and reproducible imaging methods on MR systems to fill an unmet clinical need for robust assessment of early changes in cartilage health. For ages 18-50 who sustained an acute full ACL tear in one knee with the contralateral knee uninjured. Locations: Cleveland Clinic Foundation, UCSF, University of Kentucky, Albert Einstein College of Medicine
ACL Reconstruction Outcomes 10 Years Later
In this trial, investigators will examine patients undergoing unilateral ACL reconstruction surgery to determine risk factors for osteoarthritis 10 years post-surgery. For ages 20-50 who had their surgery performed by specific doctors at specific facilities listed and participated in the two-year onsite visit. Locations: Vanderbilt University, Ohio State University, Cleveland Clinic
