Probenecid and colchicine
Drug Name(s): generic only
Class: Uric acid drugs
Type: Uricosuric, Anti-Inflammatory
Used to treat gout and gouty arthritis.
Dosage
Form(s): tablet
One pill (500 mg probenecid and 0.5 mg colchicine) twice a day.
Special Instructions
Do not drink alcohol when taking this medication.
Do not take with aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
Drink plenty of fluids while taking this medication.
Take with food or an antacid.
Potential Side Effects
Anemia; diarrhea, dizziness; fever; flushing; headache; loss of appetite; itching; increased urination; nausea; nerve pain, vomiting, rash; sore gums; stomach pain
Be Aware
Tell your doctor if you plan to have surgery involving a general anesthetic. If you are having any urine tests done, tell your doctor and the laboratory personnel that you are taking probenecid because it may affect the results of the test.
Before taking colchicine, tell your doctor if you take NSAIDs, cancer medications, heparin, nitrofurantoin or zidovudine. Tell your doctor if you have or have ever had ulcers, kidney stones, a kidney disorder, or a blood disorder.
Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking probenecid, call your doctor immediately. Also, inform your doctor if you are planning to undergo surgery that involves a general anesthetic.
Special caution is required in people who have an ongoing infection or who are using immunosuppressive drugs. Death due to colchicine toxicity have been reported in patients taking this medication with certain antibiotics and antifungals, particularly clarithromycin (Biaxin). Make sure your doctor knows about your entire health history.
If you are having any urine tests, notify your doctor and the laboratory personnel that you are taking probenecid, as it may affect test results.
