skip to main content

ES
Last Updated: 12/27/2024

Hydroxychloroquine sulfate

Drug Name(s): Plaquenil, generic

Class: DMARDs

Used to treat rheumatoid arthritis (RA), and lupus.

Dosage

Form(s): tablet

For RA: 400 mg to 600 mg daily to start, may be lowered to 200 mg once daily or 400 mg once daily, in two divided doses, for long-term use

For lupus erythematosus: 200 mg once daily or 400 mg once daily, or in two divided doses

Dosages for children: The dosages listed above are those typically prescribed for adults aged 18-65. Dosages for children can vary. Ask your doctor about the appropriate dosage for your child.

 

Special Instructions

Minimize exposure to sunlight and wear sunscreen.

Take with food or milk to avoid stomach upset.

Potential Side Effects

Abdominal cramps; blurred vision; diarrhea; headache; increased sun sensitivity; itching; loss of appetite; nausea or vomiting; rash

Be Aware

Your doctor should order periodic blood and urine tests to check for unwanted effects. Before taking any DMARD, tell your doctor if you are planning to become pregnant.

In rare cases, high doses or long-term use of hydroxychloroquine sulfate may cause changes in the central part of the eye’s retina. Tell your doctor if you have any eye problems, including any retina disorders, or if you have blurred or worsening vision; ringing in the ears or hearing loss; unusual bleeding or bruising; blue or black skin discoloration; muscle weakness. Rarely, hair loss and mood changes can occur. You should have an eye exam when you start taking this drug and on a regular basis (every 1 to 2 years) thereafter.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.