Belimumab
Drug Name(s): Benlysta
Class: Biologics
Type: B-cell inhibitor
Used in the treatment of lupus, lupus nephritis, and pediatric lupus.
Dosage
Form(s): infusion, injection, prefilled syringe
IV infusion: Based on body weight. Three IV infusions 2 weeks apart, and then every 4 weeks.
Injection: 200 mg once weekly.
Special Instructions
Women of childbearing age should use effective contraception during treatment. Self-injection should be done on the same day each week. IV Infusion is given at a doctor’s office. May be combined with corticosteroids and/or disease-modifying antirheumatic drugs (DMARDs).
Potential Side Effects
Depression; infusion reaction during or shortly after treatment (including blood pressure changes, chest pain, difficulty breathing and hives); nausea; vomiting
Be Aware
Like all biologics, this drug can suppress the immune system and may increase your risk of infections. Tell your doctor if you have an active infection. Do not start treatment if you have a serious or recurrent infection (such as pneumonia). You should be tested for tuberculosis before starting this medication. Do not get a live vaccine when taking biologics.
Tell your doctor if you have new or worsening depression, suicidal thoughts or other mood changes. Do not use this drug with IV cyclophosphamide. This drug may be less effective in African Americans
