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Last Updated: 12/27/2024

Methylprednisolone

Drug Name(s): Medrol, Solu-Medrol, Depo-Medrol

Class: Corticosteroids

Used to control inflammation in inflammatory forms of arthritis and lupus.

Dosage

Form(s): tablet, injection 

Dosages of corticosteroids vary widely, depending on which disease is being treated. Corticosteroids may have a greater effect in people who have had liver scarring (cirrhosis) or underactive thyroid (hypothyroidism); therefore, a smaller dosage may be recommended. During periods of unusual stress, your dosage may need to be increased.

Special Instructions

Take this and other oral corticosteroids with food. A single daily dose should be taken with breakfast. Sometimes the dose is split and taken several times a day.

Injections are usually injected into a joint as directed by your doctor.

Potential Side Effects

Bruising; cataracts; heart problems, including heart attack and stroke; high blood pressure, high cholesterol and high triglycerides; increased blood sugar; glaucoma; hardening of arteries (atherosclerosis); increased appetite; increased risk of infection, indigestion; insomnia; mood swings; muscle weakness; nervousness or restlessness; osteoporosis; stomach ulcers; thin skin; weight gain

Be Aware

Corticosteroids make you more likely to get an infection; the drugs also can mask the signs of an infection. Before taking any corticosteroids, tell your doctor if you have an active infection or history of tuberculosis. Also tell your doctor if you think you’ve come in contact with someone who is sick with a serious infection such as chickenpox or measles. Corticosteroids may reduce the body’s response to vaccines.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.