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Last Updated: 7/14/2025

Risankizumab

Drug Name(s): Skyrizi

Class: Biologics

Type: IL-23

Used for the treatment of psoriatic arthritis (PsA).

Dosage

Form(s): prefilled syringe, auto-injector 

150mg/mL injection every 12 weeks after two starter doses

Special Instructions

Remove drug from refrigerator and allow it to reach room temperature before injection. Do not inject into areas where the skin is tender, bruised, inflamed or affect by psoriasis.

Women of childbearing age should use effective contraception during treatment.

Potential Side Effects

Bruising, itching, pain, redness or swelling at the injection site; feeling tired, fungal skin infections, headache, upper respiratory infections

Be Aware

This and all biologics suppress the immune system and may increase your risk of infections. Tell your doctor if you have an active infection. Do not start treatment if you have a serious or recurrent infection (such as pneumonia). You should be tested for tuberculosis before starting this medication. Do not get a live vaccine when taking biologics.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.