NSAIDs may cause gastrointestinal (GI) bleeding (bleeding in the stomach or digestive tract). Topical NSAIDs may pose less risk than oral ones because the drug stays close to the site of application. COX-2 inhibitors have a lower risk of causing ulcers. The risk of stomach problems increases for people who are older than 65, have history of stomach ulcers, and take blood thinners or corticosteroids. Alcohol can worsen stomach problems.