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Last Updated: 8/29/2025

Bupivacaine

Drug Name(s): EXPAREL

Class: Local anesthetic

This anesthetic is typically used to relieve pain after surgery without opioids and is formulated to last longer than other anesthetics.

Dosage

Form(s): injection

Adults: 20 ml maximum dose

Children: varies by weight (4 mg/kg)

 

Special Instructions

Tell your doctor if you have liver problems. If your child is receiving this drug, tell the doctor if they have liver problems.

Tell your doctor if you are or may become pregnant.

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Potential Side Effects

In adults: nausea, vomiting, constipation, fever, headache

In children: nausea, vomiting, constipation, low blood pressure, low red blood count, muscle twitching, blurred vision, itching, racing heart

Be Aware

This anesthetic is used post surgery to prevent and reduce pain. It is formulated to be long-acting, potentially preventing or delaying the use of opioid pain relievers. 

Do not use with lidocaine or other local anesthetics.

Injection may cause temporary loss of feeling or muscle movement

This drug should not be injected into a joint.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.