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Last Updated: 12/27/2024

Pregabalin

Drug Name(s): Lyrica, generic

Class: Anticonvulsants

Used to treat fibromyalgia.

Dosage

Form(s): capsule, oral solution 

150 mg daily for one week; then, increase dose as needed to maximum of 450 mg daily.

Special Instructions

Taking dose at bedtime may reduce drowsiness.

Take with a full glass of water at bedtime.

Potential Side Effects

Blurred vision; dizziness; dry mouth; high blood pressure; sleepiness; swelling of hands and feet; trouble concentrating; weight gain

Be Aware

Combining any of these drugs with alcohol or other depressants (including antihistamines, narcotics and some dental anesthetics) can make side effects more severe. Also, many of the medicines used to treat fibromyalgia work by boosting the amount of serotonin in your body. Taking two or more of these drugs together could lead to a potentially life-threatening condition called serotonin syndrome. Symptoms usually begin within hours of combining the drugs and include confusion, agitation, irregular heartbeat, unstable blood pressure, tremors, muscle rigidity, nausea and vomiting. If you have these symptoms, stop taking your medication and seek immediate medical help.

Stop taking this medicine and seek immediate medical help if you have swelling of the head, neck or throat. Do not take this drug with alcohol. This drug might raise the risk of suicidal thoughts and behaviors.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.