Arthritis Today

Avocado Soybean Unsaponifiables (ASU)


Origin: A natural vegetable extract made from one-third avocado oil and two-thirds soybean oil.

Claims: Slows the progression of osteoarthritis (OA).

What we know: ASU blocks pro-inflammatory chemicals, prevents deterioration of synovial cells (which line the joints) and may help regenerate normal connective tissue.

Studies: ASU has been studied extensively studied in Europe, where it is routinely used to treat OA. A 2003 study published in the Journal of Rheumatology reported ASU inhibited the breakdown of cartilage and promoted repair.

A 2008 meta-analysis found that ASU improved symptoms of hip and knee OA and reduced or eliminated use of nonsteroidal anti-inflammatory drugs (NDAIDs).

A large, three-year study published in 2013 in the BMJ showed that ASU significantly reduced progression of hip OA compared with placebo.

Dosage: Softgel; take 300 mg daily.

The French government has tracked ASU’s safety record for more than 15 years and has yet to find any significant problems.

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