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Last Updated: 12/27/2024

Fluoxetine

Drug Name(s): Prozac, generic

Class: Antidepressants

Type: Selective serotonin re-uptake inhibitor (SSRI)

Used off-label to improve symptoms of fibromyalgia.

Dosage

Form(s): capsule, tablet

10 mg to 80 mg once a day

Special Instructions

Do not drive or perform other potentially dangerous activities until you know whether the medication will impair your ability to do them safely.

Take with food.

Talk to your doctor before stopping the drug. Your dose may need to be slowly reduced.

Potential Side Effects

Dark urine or yellow skin/eyes (liver problems); dizziness; falls, especially in the elderly; itching; mania; right upper belly pain; severe skin reaction (blisters, peeling, rash, mouth sores); suicidal thoughts; urination problems; vision problems

Be Aware

This drug can increase the risk of bleeding and bruising, especially if taken with aspirin, blood thinners or NSAIDs.

Combining this drug with alcohol or other depressants (including antihistamines, narcotics and some dental anesthetics) can make side effects more severe. Also, many of the medicines used to treat fibromyalgia work by boosting the amount of serotonin in your body. Taking two or more of these drugs together could lead to a potentially life-threatening condition called serotonin syndrome. Symptoms usually begin within hours of combining the drugs and include confusion, agitation, irregular heartbeat, unstable blood pressure, tremors, muscle rigidity, nausea and vomiting. If you have these symptoms, stop taking your medication and seek immediate medical help.

The Arthritis Foundation’s Drug Guide is meant for education — not self-medicating. The Arthritis Foundation does not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.