Shortness of breath, particularly if it occurs with a dry cough or little or no exertion, could signal a potentially serious problem in your lungs, such as blood clots or scarring. If you are taking methotrexate, another possible cause may be methotrexate pneumonitis, which causes shortness of breath accompanied by a dry cough and fever. Don't confuse this symptom with exercise exertion. Call your doctor for an evaluation if you often feel shortness of breath.
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