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The Role of Joint Mechanics and Biology in Osteoarthritis: Pathogenesis and Implications for New Interventions
Friday October 26
| 2:00 PM: Poster Session | |
| 4:00 PM: Welcome and Introduction to SNOW V | Chair: John Hardin, MD |
| The Arthritis Foundation’s Strategic Plan for OA | Jennifer Griffiths, PhD |
| National Institute of Arthritis and Musculoskeletal and Skin Diseases OA Research | Gayle Lester, PhD |
| The OA Alliance – A Patient-Based Perspective | Dave Mekemson Robin Katzanek, PT, PhD Patrick Boyle, PT, DPT |
| The Food and Drug Administration Perspective | Janet Woodcock, MD |
| Discussion | |
| 6:00 PM: Reception & Poster Session | |
| 7:00 PM: Dinner | |
Saturday October 27
| 7:30 AM: Continental Breakfast | |
| 8:30 AM: Session I: The Joint as an Organ | Chair: Robin Poole, PhD, DSc |
| How the Joint is Designed -- an Anthropological Perspective | Bruce Latimer, PhD |
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Discussion
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Steve Goldring, MD Carla Scanzello, MD, PhD Linda Sandell, PhD |
| Discussion | |
| 10:15 AM: Break | |
| 10:30 AM: Session II: Assessing the Functional Capacity and Disease Risk of the Joint | Chair: Joel Block, MD |
| Functional and Structural Assessment of the Joint | Tom Andriacchi, PhD Felix Eckstein, MD Richard Souza, PhD |
| Discussion | |
| The OARSI Biomarker Consortium initiative | Michael Nevitt, PhD, MPH |
| Discussion | |
| 12:00 PM: Lunch | |
| 1:00 PM: Session II Continues | Chair: Michael Nevitt, PhD, MPH |
| New MRI Technologies: Prospects for Application in Multicenter Clinical Trials | Garry Gold, MD |
| Discussion | |
| Biochemical Measures | Dick Heinegard, MD, PhDH |
| Discussion | |
| 2:30 PM: Break | |
| 2:45 PM: Session III: Disease Mechanisms That Impact the Joint | Chair: Mary Goldring, PhD |
| Trauma | Jody Buckwalter, MD |
| Obesity | Steve Messier, PhD |
| Pathomorphology and Pathomechanics | Shane Nho, MD |
| Age | Richard Loeser , MD |
| Discussion | |
| 4:00 PM: Break | |
| 4:15 PM: Session IV: Scientific Discoveries Supporting the Joint as an Organ | Chair: Linda Sandell, PhD |
| Autophagy | Chris Weihl, MD, PhD Martin Lotz, MD |
| Oxidative Stress and Tissue Injury | Laura Santambrogio, MD, PhD |
| Discussion | |
| 5:15 PM: Conclude for the Day | John Hardin, MD |
Sunday October 28, 2012
| 7:30 AM: Continental Breakfast | |
| 8:30 AM: Session V: The Path to an Intervention | Chair: Peter Mitchell, PhD |
| The Potential of Stem Cells and Regenerative Medicine | Rocky Tuan, PhD |
| Stem Cells, Obesity and Biomechanics | Farshid Guilak, PhD |
| Discussion | |
| Potential for Pharmacologic Intervention | Steve Abramson, MD |
| Discussion | |
| 10:00 AM : Break | |
| 10:15 AM: Session VI: Anterior Cruciate Ligament Injury as an OA Model | |
| Overview of Clinical Trials of ACL Injuries | Elena Losina, PhD Jeffrey Katz, MD |
| Orthopedic Perspective on ACL Injuries | Brian Cole, MD, MBA |
| The ACL Pilot Study | Christian Lattermann, MD |
| Discussion | |
| The ACL Intervention Initiative | Marc Hochberg, MD Linda Sandell, PhD |
| Discussion | |
| 12:00 PM: Conclusion | John Hardin, MD |
Special Thanks to Our Supporters
With additional gratitude to our scientific partners
AOSSM, FNIH, NIAMS and OARSIand to Gordon & Carole Segal
