Arthritis Today

Tramadol (extended release)


Drug Class:

Analgesics (Atypical opioid)

Brand Names




100 to 300 mg once a day.

Potential Side Effects


Constipation; dizziness; drowsiness; itching; lightheadedness; mental confusion; nausea; shortness of breath; urinary retention; vomiting.

Special Instructions

  • Do not increase the dose on your own or stop treatment abruptly unless told to do so by a doctor. Do not drive, operate machinery or perform other potentially dangerous activities until you know whether the medication will affect your ability to do them safely.

Be Aware

  • Opioids can slow breathing and suppress the cough reflex. Before taking an opioid, tell your doctor if you have a history of lung disease or breathing difficulties. Taking opioids with certain other drugs can increase the risk of dangerous side effects. Especially tell your doctor if you take antihistamines (allergy medications), tranquilizers, sleeping pills, muscle relaxants or other pain medication, or if you have a history of alcohol or drug abuse.
  • Seizures have been associated with the use of tramadol. Taking this drug with certain antidepressants or with other opioids may increase this risk.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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