Arthritis Today



Drug Class:


Brand Names




150 mg daily for one week; then, increase dose as needed to maximum of 450 mg daily. 

Potential Side Effects


Blurred vision; dizziness; dry mouth; high blood pressure; sleepiness; swelling of hands and feet; trouble concentrating; weight gain.

Special Instructions

  • Taking dose at bedtime may reduce drowsiness.
  • Take with a full glass of water at bedtime.

Be Aware

  • Combining any of these drugs with alcohol or other depressants (including antihistamines, narcotics and some dental anesthetics) can make side effects more severe. Also, many of the medicines used to treat fibromyalgia work by boosting the amount of serotonin in your body. Taking two or more of these drugs together could lead to a potentially life-threatening condition called serotonin syndrome. Symptoms usually begin within hours of combining the drugs and include confusion, agitation, irregular heartbeat, unstable blood pressure, tremors, muscle rigidity, nausea and vomiting. If you have these symptoms, stop taking your medication and seek immediate medical help.
  • Stop taking this medicine and seek immediate medical help if you have swelling of the head, neck or throat. Do not take this drug with alcohol. This drug might raise the risk of suicidal thoughts and behaviors.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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