Drug Class:


Brand Names

Otrexup, Rasuvo, Rheumatrex, Trexall



7.5 to 30 mg in a single weekly dose.

Dosages for children: The dosages listed above are those typically prescribed for adults aged 18-65. Dosages for children can vary. Ask your doctor about the appropriate dosage for your child.

Potential Side Effects


Abdominal discomfort; chills; dizziness; fever; general feeling of illness; hair loss; headache; increased sun sensitivity; itching; liver problems; low blood counts; mouth sores; nausea; rash; shortness of breath; yeast infections.

Special Instructions

  • Avoid aspirin and other salicylates.
  • Drink plenty of fluids while taking this medication.
  • Your doctor may prescribe folic acid to reduce side effects.
  • Minimize exposure to sunlight and wear sunscreen.

Be Aware

  • Your doctor should order periodic blood and urine tests to check for unwanted effects. Before taking any DMARD, tell your doctor if you are planning to become pregnant.
  • Tell your doctor immediately if you have a dry cough, fever or difficulty breathing, as these symptoms may be associated with serious medication side effects.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

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