Arthritis Today

Hydrocodone bitartrate with ibuprofen


Drug Class:

Analgesics (Opioid)

Brand Names

Reprexain, Vicoprofen



In a combination pill, 7.5 mg hydrocodone and 200 mg ibuprofen every 4 to 6 hours as needed, no more than five pills in a 24-hour period. (Amount of acetaminophen varies.)

Potential Side Effects


Abdominal pain; anxiety; diarrhea; dizziness; drowsiness; dry mouth; flatulence; infection; insomnia; itching; nervousness; sweating; swelling of the feet and ankles; urinary retention; vomiting; weakness.

Special Instructions

  • Do not take with other prescription or over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Do not increase the dose on your own or stop treatment abruptly unless told to do so by a doctor. Do not drive, operate machinery or perform other potentially dangerous activities until you know whether the medication will affect your ability to do them safely.

Be Aware

  • This medicine contains ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID). Before taking any type of NSAID, tell your doctor if you drink alcohol or take blood thinners (including warfarin), ACE inhibitors, lithium or furosemide. Also report any sensitivity or allergy to aspirin or similar drugs. All NSAIDs may cause an increased risk of serious blood clots, heart attacks and stroke, which can be fatal. This risk may increase with dose and duration of use. Patients who have or who are at risk for cardiovascular disease may be at greater risk for these complications. NSAIDs should not be used for pain if you are going to have coronary bypass surgery. Do not take NSAIDs late in pregnancy.
  • Opioids can slow breathing and suppress the cough reflex. Before taking an opioid, tell your doctor if you have a history of lung disease or breathing difficulties. Taking opioids with certain other drugs can increase the risk of dangerous side effects. Especially tell your doctor if you take antihistamines (allergy medications), tranquilizers, sleeping pills, muscle relaxants or other pain medication, or if you have a history of alcohol or drug abuse.

The Arthritis Today Drug Guide is meant for education – not self-medicating. Arthritis Today, the Arthritis Foundation and the Drug Guide Medical Review Panel do not endorse any products mentioned in this guide. While we endeavor to keep the information up to date, we make no representations or warranties about the completeness of the information provided.

About Arthritis Today Drug Guide | Privacy Policy | Medical Review Panel