Lee C. Howley Sr. Prize for Arthritis Research
Wayne M. Yokoyama, MDThe Lee C. Howley Sr. Prize for Research in Arthritis recognizes those researchers whose contributions during the previous five years have represented a significant advance in the understanding, treatment or prevention of arthritis and rheumatic diseases. It is a fitting memorial tribute to Lee C. Howley Sr., former chairman of Revco D.S., Inc., who was instrumental in the establishment of the Revco Arthritis Research Center at Case Western Reserve University in Cleveland, Ohio.
The Arthritis Foundation extends its gratitude to the Howley family on behalf of the estimated 50 million Americans who have arthritis for making the Lee C. Howley Sr. Prize for Research in Arthritis possible. The recognition that this program offers for excellence in arthritis research will ensure that the search will continue for cures to the more than 100 forms of arthritis and the rheumatic diseases. The Howley family's expression of commitment offers hope that one day the problems of arthritis will be solved.
The recipient of the 2010 Lee C. Howley Sr. Prize for Arthritis Research is Wayne M. Yokoyama, MD, of the Washington University School of Medicine in St. Louis, where he holds the Sam J. and Audrey Loew Levin Chair for Research in Arthritis and is Director of the Medical Scientist Training Program.
Dr. Yokoyama established the molecular basis of target cell recognition by natural killer cells. He was the first to identify a gene cluster encoding receptors responsible for inhibiting or activating natural killer cells, and to show that these receptors specifically interact with ligands that are expressed on the target cell surface.
2011 Lee C. Howley Sr. Prize for Arthritis Research Guidelines
Deadline for Nominations: August 1, 2011




