| DRUG |
BRAND(S) |
DOSAGE |
SPECIAL INSTRUCTIONS |
POSSIBLE SIDE EFFECTS |
BE AWARE |
 |
|
Allopurinol
|
Lopurin, Zyloprim
|
100 to 800 mg per day in a single dose. The dose is adjusted to achieve a serum uric acid level lower than 6 mg/dl.
|
Take immediately after a meal. Stop taking medication at the first sign of a rash, which may indicate an allergic reaction.
|
Skin rash, hives or itching
|
Before taking this drug, let your doctor know if you use azathioprine (Imuran) or if you have kidney disease. Acute gout attacks
are common when this drug is started. These attacks can be minimized by taking lower doses and by taking the drug with colchicine or
NSAIDs. Never start or stop allopurinol during a flare.
|
 |
|
Colchicine
|
Available only as generic
|
0.6 to 1.2 mg per day in 1 to 2 doses for prevention; 0.6 mg every 1 or 2 hours (no more than 8 doses per day) to stop acute attacks
|
Take with food if stomach upset occurs. Drink plenty of fluids.
|
Diarrhea; nausea or vomiting; neuropathy; stomach pain
|
Before taking this drug, tell your doctor if you have intestinal, kidney or liver disease. Special caution is required in people who have an
ongoing infection or are using immunosuppressive drugs.
|
 |
|
Probenecid
|
Benemid, Probalan
|
500 to 3,000 mg per day in 2 or 3 divided doses
|
Take with food or an antacid. Do not take with aspirin or other NSAIDs. Avoid alcohol.
|
Headache; loss of appetite; nausea or vomiting
|
These drugs may interfere with the copper sulfate urine sugar tests taken by people with diabetes and lead to false positive readings.
|
 |
|
Probenecid and colchicine
|
ColBenemid, Col-Probenecid, Proben-C
|
1 tablet (500 mg probenicid and 0.5 mg colchicine) 2 times per day
|
Take with food or an antacid. Drink plenty of fluids. Do not take with aspirin or other NSAIDs. Avoid alcohol.
|
Diarrhea; headache; loss of appetite; nausea or vomiting; stomach pain
|
Before taking this drug, tell your doctor if you use cancer medications, heparin (Calciparine, Liquaemin), nitrofuratoin (Furadantin, Macrobid, Macrodantin), NSAIDs or zidovudine (Retrovir), or if you have any of the following: blood disease, intestinal disease, kidney disease or kidney stones.
|