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SEA Syndrome
(Seronegativity, Enthesopathy, Arthropathy)


 
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Children who appear to have one of the juvenile spondyloarthropathies, but whose illness cannot be classified specifically into one of the more clear-cut categories, can be diagnosed with SEA syndrome.

Signs and Symptoms

  • Negative rheumatoid factor (seronegativity)
  • Affects large joints, such as the hips, knees and ankles 
  • Joints are affected on one side of the body only (arthropathy)
  • Inflammation and tenderness where the tendons meet the bones (enthesopathy)

Long-Term Effects
Some children's condition will never progress from the SEA syndrome stage. Others, however, will go on to develop juvenile psoriatic arthritis, juvenile enteropathic arthritis or juvenile ankylosing spondylitis. Your doctor will review any new symptoms or problems at each visit to determine if your child has any of these diseases.

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